With current methods, the likelihood of pregnancy after a frozen embryo transfer is comparable to that after a fresh embryo transfer. The key to a successful outcome is careful planning: the transfer is timed so that the uterus is as receptive as possible to embryo implantation. We always select the most appropriate treatment approach on an individual basis, taking your overall situation into account.
A frozen embryo transfer can be performed either in your natural menstrual cycle or in a cycle supported by hormone replacement therapy.
In this approach, we utilize your body’s own hormonal function.
Natural cycle: Timing is determined based on a home ovulation test (LH test).
In both options, a corpus luteum forms in the ovary after ovulation and produces progesterone, which is essential for embryo implantation. In addition, we often use light supplemental progesterone medication. A blastocyst-stage embryo is thawed and transferred 6–7 days after ovulation or after the trigger injection.
A hormone replacement cycle is used if your natural menstrual cycle is irregular or if we want to optimize timing precisely with medication.
Treatment is started with estrogen (tablets or patches) at the onset of menstruation.
Ultrasound examination is used to confirm that the endometrial lining grows to an adequate thickness. If the lining is not thick enough, the estrogen dose is increased and a repeat ultrasound is scheduled.
Once the lining is ready, progesterone treatment is initiated; this determines the timing of embryo thawing and transfer.
During a hormone replacement cycle, we usually measure progesterone levels either on the day before transfer or on the morning of the transfer. If the level is insufficient, the dose can still be increased to ensure the best possible chance of establishing a pregnancy.
Patients with endometriosis or adenomyosis often require a specific approach. In these cases, we commonly aim to suppress the body’s own estrogen production as much as possible before starting the hormone replacement cycle, using pre-treatment with a GnRH agonist. Estrogen therapy is then initiated individually, usually after one or sometimes two GnRH agonist injections. This treatment is commonly associated with menopausal-type symptoms due to intentionally low estrogen levels.
In selected cases, the following supportive medical treatments may be added individually to the approaches described above:
If you are considering fertility treatment or want to know more about embryo freezing, our experts at Ovumia are happy to help.
Book an appointment for your first visit and ask more about embryo freezing – we are here to support you on your journey towards your desired pregnancy. During the first visit, an Ovumia doctor will interview the woman or couple, review the information provided in advance, and listen to your wishes.
In Ovumia, we are always ready to help you!
