The AMH level can provide valuable information about a woman’s reproductive health – which is why it has become one of the most sought-after tests.
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AMH, or Anti-Müllerian hormone, is secreted from small pre-antral follicles in the ovaries and from the cells of small antral follicles. All of these small follicles cannot be reliably assessed with ultrasound. A blood test is an easy, quick, and reliable way to measure the current state of your AMH levels.
The most common reason for AMH measurement is to assess the functional reserve of the ovaries. AMH determination is also used when premature ovarian failure is suspected.
At menopause, the AMH value decreases to undetectable levels. Similarly, in polycystic ovary syndrome (PCOS), the AMH value can be quite high. The AMH level does not directly reflect the female fertility. The AMH value can be used to guide the dose of hormones used for ovarian hormone stimulation in infertility treatments. A low value reflects a significant risk that the ovaries will not respond well to hormonal stimulation in IVF treatment. Even with a high dose of FSH, the desired follicle growth and desired number mature eggs for fertilization will probably not be achieved.
The AMH value is significantly dependent on age and interpretation should always be based on the patient's age. The value naturally decreases with age in an individual fashion.
The AMH level does not reflect the quality of the oocytes (eggs), which is primarily dependent on the female age. AMH value alone cannot be used reliably to evaluate female fertility.
The AMH level is determined from a blood sample. In contrast to the levels of other hormones that reflect ovarian function, the menstrual cycle has only a small effect on the AMH level. It is worth noting that combined contraceptive hormone preparations lower the AMH level, and AMH measurement cannot be considered reliable during their use. Typically the treatment should be discontinued for three months to achieve reliable AMH measurements.
